"There are exceptions. But by and large, Latin America's political culture is sicker than it is healthy," the pontiff told bishops from across Peru, a country that has seen its political parties and presidents plagued by dishonesty and graft.
"What is wrong with Peru, that when one finishes being president one ends up behind bars?" Francis wondered aloud.
"(Ollanta) Humala, is in jail, (Alejandro) Toledo is in jail (living in US awaiting extradition);(Alberto) Fujimori was detained until just now; Alan Garcia, isn't sure if he's in or out: What is wrong morally?" he asked.
"If we let ourselves be led by people who only speak the language of corruption, we are done for," the Argentinian pontiff warned, using a popular Peruvian slang term and earning some laughter.
Earlier Sunday, the 81-year-old pope delivered a homily to 500 nuns, and met with bishops.
The pontiff on Saturday had urged Latin America's faithful to fight rampant violent crime against women, comments which came during a mass in Peru's largest northern city of Trujillo.
"I wish to invite you to combat a plague across our Latin American region: the numerous cases of violent crimes against women, from beatings to rape to murder," Francis told the crowd.
While in Peru, the pope railed against "great business interests" for endangering the Amazon and its indigenous people and lashed out again at corruption in politics.
"There is so much damage done by this... thing that infects everything," Francis said. "And it's always the poorest and the environment that get the short end of the stick."
On Friday, he sounded a stark warning about the future of the rainforest and indigenous tribe members, saying they had "never been so threatened."
Francis began his Latin American visit in Chile last Monday.
There, he highlighted the plight of vulnerable immigrants, apologised to victims of sexual abuse by Catholic priests, prayed with survivors of Augusto Pinochet's brutal dictatorship, and called for protection of Chile's persecuted indigenous people.
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