The surprise offensive was announced yesterday by the Tahrir al-Sham alliance, which is dominated by the jihadist Fateh al-Sham Front, once linked to Al-Qaeda.
"This afternoon, Tahrir al-Sham began preparing for military operations against (regime) army positions in Hama province," said Tahrir al-Sham press officer Imad al-Din Mujahid.
Tahrir al-Sham published photos of a massive explosion that it said was a suicide attack against a government checkpoint inside Suran.
Hama province is of strategic importance to President Bashar al-Assad, separating opposition forces in Idlib from Damascus to the south and the regime's coastal heartlands to the west.
The British-based monitor said the jihadists and rebel groups seized Suran and eight surrounding checkpoints within hours, despite heavy air strikes by government warplanes.
The town has exchanged hands several times in Syria's six-year conflict, with government forces recapturing it in late October from opposition factions.
The Free Idlib Army, which is taking part in the offensive, said it targeted the Hama military airport and other government positions yesterday.
Rebel groups and Tahrir al-Sham were also waging an offensive in Syrian capital yesterday in a bid to link two neighbourhoods they control in Damascus.
Syria's conflict erupted in March 2011 with protests against Assad's rule, but has evolved over the years into a complex civil war.
More than 320,000 people have been killed and millions more displaced by the conflict.
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