The 39-year-old actress was feted by Jennifer Aniston, Matthew McConaughey, Kate Hudson, Sofia Vergara, and Jennifer Garner among others, reported Ace Showbiz.
"I really thought if I worked hard and did my very, very best, one day I could get Matthew McConaughey to come on a big public stage and say really nice things about me," Witherspoon joked after given the award by the actor.
"I actually think that's pretty much every Southern woman's dream. This whole experience is just overwhelming and unbelievable because I'm really just a girl from Nashville who had a dream," she said.
She joined another honouree, DreamWorks Animation honcho Jeffrey Katzenberg. Isla Fisher and Laura Dern were among the attendees. Kenny Chesney performed a rendition of "Wild Child".