If things work out they are expected to share screen with Oprah Winfrey in the film adaptation of 1962's classic children's book by Madeleine L'Engle, according to The Hollywood Reporter.
Witherspoon is being considered for the role of a former celestial being named Mrs Whatsit, while Kaling will play a literature-quoting known as Mrs Who.
They will complete the trio of supernatural beings including Mrs Which, who will be portrayed by Winfrey.
Ava DuVarnay will direct the fantasy film from a screenplay provided by "Frozen (2013)" scribe and co-director Jennifer Lee.
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