Forex dealers said dollar strengthening against other currencies overseas as investors awaited a statement from the US central bank weighed on the rupee sentiment.
Domestic stock markets opening higher limited the losses, they added.
The rupee had ended lower by 4 paise at 64.38 per dollar yesterday at the Interbank Foreign Exchange market.
Meanwhile, the benchmark BSE Sensex rose 49.58 points, or 0.15 per cent, to 32,277.85 in early trade.
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