"They were crossing the river on makeshift rafts in a village south of Mayadeen," Observatory director Rami Abdel Rahman said, adding that three children were among those killed overnight.
Russia has in recent days intensified its air raids in support of Syrian regime forces battling jihadists across the country.
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Mayadeen has been under IS control since 2014, when the group swept across swathes of Iraq and Syria and proclaimed a "caliphate", but regime forces this week advanced to within five kilometres of the town.
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