The film, which will begin production in 2016, will be the rapper's third stint as a director after previously helming 2012's "The Man With The Iron Fists" and "Coco", reported Billboard magazine.
"Breakout" follows the story of a young photographer, who is falsely arrested in Bangladesh for drug trafficking.
Richard D'Ovidio wrote the screenplay based on a story he originated with Nicole D'Ovidio. It will be released by Amasia Entertainment.
Michael Helfant and Bradley Gallo, from Amasia, said in a statement, "The multi-talented RZA has mastered the art of music, acting and filmmaking.
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