While Olympic bronze medallist Saina fought hard before going down 21-16 10-21 19-21 to a lower-ranked Yao Xue of China in a 56-minute contest, Sindhu lost to sixth seed Yeon Ju Bae of Korea 16-21 19-21 in 45 minutes at the Putra Stadium.
World No. 8 Saina, who had endured a tough season last year as she could not win a single title, failed to turn around her fortunes in her season opener here.
Despite it being a close affair till 12-12, Saina kept her calm to seal the opening game 21-16.
But the Indian was in for a rude shock in the second game as the Chinese girl maintained an upper-hand throughout. Saina, surprisingly, could not catch her opponent even once during game two.
After taking the initial lead, Xue simply kept on moving ahead and opened up a massive gap. She eventually sealed the second game without breaking a sweat.
In the decider, Saina got her act together and took a 7-4 lead before moving to 10-8.
Saina, however, showed a lot of character as she fought back to pocket three successive points and reduce the margin to 17-18 before catching up with her rival at 19-19.
But the Chinese raised her game when it mattered the most and bagged two quick points to stun her fancied Indian opponent.
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