44-year-old Martin Salia, a native of Sierra Leone and a US resident, was infected with the deadly hemorrhagic fever while treating patients in his home country and was flown to Omaha, Nebraska for treatment on Saturday.
In a statement issued today, Nebraska Medical Centre said that Dr Salia who was being treated in its biocontainment unit died as a result of the advanced symptoms of the disease.
"He was placed on dialysis, a ventilator and multiple medications to support his organ systems in an effort to help his body fight the disease."
Salia was the 10th person with Ebola to be treated in the United States, and the second to have died from the infection.
In October, a Liberian man, Thomas Eric Duncan, died at a hospital in Texas of the virus which has killed thousands of people in West Africa.
The surgeon and his wife lived in New Carrollton, Maryland, a suburb of the US capital Washington. They have two children, age 12 and 20.
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