Lahore Traffic Police chief capt (R) AhmedMobeen and Senior Superintendent Police Zahid Gondal were among five police personnel killed in the blast, police officials said.
Lahore police chief Amin Wains confirmed the death of Mobeen. He, however, did not confirm about other casualties. "I can confirm the death of Mr Mobeen at the moment," he said.
At least 16 people were killed in the powerful blast that ripped through the protest rally, officials said.
The Jamat-ul-Ahrar faction of the outlawed Tehreek-i- Taliban Pakistan claimed responsibility for the attack.
The group had claimed responsibility for a blast on March 27 last year at Gulshan-e-Iqbal Park in Lahore that left 75 people dead, mostly Christians who were celebrating Easter.
The security forces have cordoned off the area and the inner cordon was taken over by Army personnel. Forensic teams were collecting evidence and had started investigations.
"The chemists were protesting against the controversial drug regulations the government has recently imposed. Several protesters were lying on the road before the rescuers shifted them," said Ishtiaq Ahmed, a representative of the Lahore Chemist Association.
DIG Mobeen had survived an attempt to his life during his posting in Balochistan.
A Lahore police officer told PTI that apparently it was a suicide attack and the bomber targeted the police personnel present there. "The target was not the protest demonstration but the police officers," he added.
A TV footage shows that a motorcyclist dragging his bike close to police officers and blew himself up. Mobeen is seen in the footage negotiating with the protesters.
Prime Minister Nawaz Sharif condemned the blast and said that fight against militants would continue. He promised to take revenge for the lives lost in today's terror attack.
"We have fought this fight against the terrorists among us, and will continue to fight it until we liberate our people of this cancer, and avenge those who have laid down their lives for us," Sharif said in a statement.
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