There were bouts of volatility in between, which saw engineering, banking, auto and IT stocks come under pressure.
After starting lower, the Sensex closed at 24,469.57, down 22.82 points, or 0.09 per cent.
The index gained 530.18 points in the last three sessions.
The broader Nifty ended lower by 13.10 points, or 0.18 per cent, at 7,424.65.
Selling in view of the January series futures and options expiry, depressed corporate numbers so far and mixed global leads all ganged up against markets, brokers said.
L&T plunged 2.72 per cent, Axis Bank 2.06 per cent, BHEL 1.97 per cent, Adani Ports 1.86 per cent and HDFC Ltd 1.67 per cent.
Stocks of Bharti Airtel and ICICI Bank too lost 2.32 per cent and 1.69 per cent, respectively, ahead of their quarterly numbers later in the day.
Other big losers were Hero MotoCorp, Tata Steel, Wipro, Tata Motors, Cipla, Infosys, Maruti Suzuki and HDFC Bank.
"The Fed kept interest rates unchanged and acknowledged that the US economy was slowing down... Expiry of derivative contracts weighed on the sentiment of the Street," said Gaurav Jain, Director, Hem Securities.
In Asia, the benchmark Shanghai Composite sank 2.92 per cent, the third straight loss, despite Chinese central bank's huge cash injection into the financial system.
Japan's Nikkei was down 0.71 per cent, but Hong Kong's Hang Seng edged up 0.75 per cent.
Sector-wise, capital goods suffered the most by losing 1.72 per cent, followed by banking (0.91 per cent), consumer durables (0.82 per cent) and auto (0.42 per cent).
In the 30-share Sensex pack, 16 lost and 14 advanced.
"On a positive note, oil is inching up and Europe market is moving higher. India is tending to have found a floor at least in the near-term," said Vinod Nair, Head-Fundamental Research, Geojit BNP Paribas Financial Services Ltd.
The market breadth turned negative as 1,313 shares ended lower, 1,243 advanced, while 178 ruled steady.
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