Losses in counters like ONGC, GAIL, RIL, SBI, Axis Bank, Mahindra and Mahindra, Maruti Suzuki, ITC and Larsen & Toubro mainly weighed on the market sentiment.
Bucking the general weak trend, pharma sector stocks such as Dr Reddys Lab, Ranbaxy Cipla and Sun Pharma ended higher -- providing investors some relief.
The BSE Sensex ended down 106.38 points, or 0.40 per cent, to end at 26,314.29 after surging to 26,504.52 intra- day. Yesterday, the 30-share benchmark had ended at its all-time closing high of 26,420.67 and had also logged intra-day life high of 26,530.67. In previous six days of straight gains, it had gained over 1,091 points.
"Investors booked profits after the recent surge which saw them reach record high levels. Buying interest was seen in IT and pharma stocks on account of a weak rupee against the dollar," said Rakesh Goyal, Senior Vice President, Bonanza Portfolio.
Sectorwise, the BSE Oil and gas index suffered the most by falling 1.32 per cent, followed by FMCG Index 0.70 per cent and Auto Index 0.56 per cent.
Meanwhile, Foreign Portfolio Investors (FPIs) bought shares worth a net Rs 559.39 crore yesterday, as per provisional data from the stock exchanges.
In Asia, most indices edged higher following a positive lead from Wall Street, where stocks picked up on encouraging US data before a keynote speech this week by Fed chief.
However, Europe's main stock markets dipped at the start of trading on Wednesday after two days of strong gains. London's benchmark FTSE 100 index fell 0.12 per cent and Frankfurt's DAX 30 edged down 0.05 per cent. The CAC 40 index in Paris also lost 0.10 per cent.
