The 30-share barometer, which had gained 171.15 points yesterday, fell 100.98 points, or 0.39 per cent, to 25,722.01, with capital goods, metal, power and oil & gas sector stocks contributing to the fall in a big way.
Also, the NSE Nifty declined 15.20 points, or 0.19 per cent, to 7,830.75.
Brokers said squaring-up of positions by participants with today being the last trading session of the September derivatives expiry and a weak trend at other Asian bourses following overnight losses on the Wall Street as weak Chinese and US factory data added to growth worries dampened sentiment.
The Dow Jones Industrial Average ended 0.31 per cent lower in yesterday's trade.
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