Researchers have long recognised that shift work can contribute to metabolic risk because of the continual disruption to the circadian system.
Shift workers are more likely to develop metabolic syndrome, coronary heart disease and type 2 diabetes than employees with regular daytime shifts.
Sleep disruption is among the factors that have contributed to rising rates of diabetes and obesity.
"Social jetlag refers to the mismatch between an individual's biological circadian rhythm and their socially imposed sleep schedules," said Patricia M Wong, of the University of Pittsburgh in US.
"These metabolic changes can contribute to the development of obesity, diabetes and cardiovascular disease," she said.
Researchers examined sleep patterns and cardiometabolic risk in a group of 447 men and women who took part in the Adult Health and Behaviour Project Phase 2 study in US.
The participants were between the ages of 30 and 54, and they worked at least 25 hours a week outside the home.
Among the participants, nearly 85 per cent had a later halfway point in their sleep cycle - a measurement known as midsleep - on free days compared to work days.
The other 15 per cent had an earlier midsleep on free days than on work days.
Participants who had a greater misalignment between their sleep schedules on free and work days tended to have poorer cholesterol profiles, higher fasting insulin levels, larger waist circumference, higher body-mass index and were more resistant to insulin than those who had less social jetlag.
The study was published in the Journal of Clinical Endocrinology and Metabolism.
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