Putting the ball in government's court, RBI Governor Raghuram Rajan kept the key interest rate unchanged saying that further easing will depend on "structural reforms" in the forthcoming Budget as well as macroeconomic factors.
The apex bank, which had cut interest rate by 125 basis points in 2015, retained the repo rate at 6.75 per cent.
Besides, rupee weakening by 14 paise to 67.98 against the dollar also weighed on the domestic equities.
Globally investors are shunning risky assets like oil, equities and commodities, he added.
Back home, the BSE Sensex opened higher at 24,868.21 and moved up to 24,928.75 on initial buying. But on profit-booking it declined afterwards to 24,460.53 before finishing at 24,539, showing a loss of 285.83 points or 1.15 per cent.
The NSE Nifty also broke below the 7,500-mark by falling 100.40 points or 1.33 per cent to 7,455.55. Intra-day, it shuttled between 7,576.30 and 7,428.05.
Bucking the trend, shares of Bajaj Auto gained 1.48 per cent to Rs 2,362.55 after the company reported 1.78 per cent growth in total sales in January.
In overseas markets, Asian equities ended lower on fresh weakness in oil prices. But, Chinese stocks ended up by 2.26 per cent after the country's central bank injected more liquidity into the financial system. Other indexes like Hong Kong, Japan, Singapore, South Korea and Taiwan declined by 0.32 per cent to 0.89 per cent.
FII withdrawals were the reasons for the carnage in the domestic markets," said Alex Mathews, Head - Research of Geojit BNP Paribas.
Out of the 30-share Sensex pack, 25 scrips ended lower.
Tata steel took the biggest hit as it plunged by 7.18 per cent followed by NTPC 4.28 per cent, Sun Pharma (4.12 pc), BHEL (3.99 pc), Cipla (3.98 pc), ONGC (3.60 pc), Adani Ports (3.42 pc), ICICI Bank (3.02 pc), Coal India (2.92 pct), Tata Motors (2.56 pc), RIL (2.54 pc) and SBI (2.00 pc).
Other prominent losers were Maruti Suzuki, M&M, GAIL India, TCS, HDFC Bank and Asian Paints.
The small-cap ended in the negative zone by falling 1.25 per cent and the mid-cap dropped 1.74 per cent.
Among BSE sectoral and industry indices, metal fell 4.33 per cent followed by energy 2.69 per cent, oil&gas (2.59 pc), healthcare (2.46 pc), power (2.42 pc), utilities (2.11 pc), industrials (1.79 pc), realty (1.71 pc) and bankex (1.68 pc), while telecom rose by (0.41 pc).
The market breadth turned negative as 1,843 stocks ended lower, 859 closed higher while 106 ruled steady. The total turnover rose to about Rs 2,935 crore from Rs 2,603.85 crore yesterday.
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