The attack was carried out shortly after 'iftar', the meal that ends the daily fast in the holy month of Ramzan. Geo News channel quoted intelligence sources as saying that five terrorists, wearing suicide vests and carrying automatic weapons, were involved in the attack.
One attacker rammed an explosives-laden vehicle into the wall of the Inter-Services Intelligence office at Barrage Colony in Sukkur, Sindh's third largest city located 500 km from the financial hub of Karachi.
Two officials, a Deputy Director of ISI and an employee of the Commissioner House, were killed in the attack.
More than 40 people were injured in the attack, police said.
Earlier media reports had said that seven people were killed in the attack but later they clarified that the seven killed, included five militants.
Police said that all five attackers were killed and the area had been cleared of militants.
Witnesses said they had heard at least four blasts within the high-security compound that houses the ISI office and residences of intelligence, police and civil officials.
A police official in Sukkur, who did not want to be named, told PTI that buildings housing government offices were razed by the blasts.
Deputy Inspector General of Police Javed Odho told the media the ISI office was the target of the attack. "The blasts took place in a compound that houses the offices of senior police officials and an intelligence agency," he said.
Odho said that security and rangers personnel had to surround the compound after the blasts and a heavy exchange of fire took place between them and the militants before the area was cleared of the militants.
No group claimed responsibility for the attacks. The Taliban have targeted offices of the ISI and other security agencies in Punjab and Khyber-Pakhtunkhwa provinces but such attacks are rare in Sindh.
President Asif Ali Zardari condemned the attack in a statement.
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