With tens of thousands of civilians fleeing, Kerry said he is working to ensure their safety and to save Aleppo "from being absolutely, completely destroyed."
Kerry and European and Arab diplomats are meeting members of Syria's opposition in Paris on Saturday, hosted by French Foreign Minister Jean-Marc Ayrault.
Meanwhile, US and Russian military experts and diplomats are meeting in Geneva today to work out details of the rebels' exit from eastern Aleppo.
Speaking in Paris yesterday night, Kerry acknowledged "people are tired of these meetings. ... But what am I supposed to do? Go home and have a nice weekend in Massachusetts while people are dying?"
After days of intense bombing, the US ambassador to the UN, Samantha Power, acknowledged this week that diplomacy has "not delivered for the people of Aleppo."
"We have engaged in that exercise in good faith for many many months. But all that has happened in that period is that no food has arrived. No medical evacuations have occurred from eastern Aleppo. And the regime backed by Russia has pulverized schools, hospitals, civilian neighborhoods," she said.
Russia says it is helping Assad target Islamic extremists who have staged attacks around the world.
Russia's UN ambassador Vitaly Churkin said yesterday extremists had "subjugated" Syria's opposition. "The phantom concept of the Syrian moderate opposition failed," he said, according to the Tass news agency.
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