The duo have played a key role in Mohun Bagan's success this season as they had blanked the Hong Kong outfit 4-0 in the first leg March 9 en route to logging 11 points from five matches in Group G.
Unbeaten Mohun Bagan are five points clear of South China, who have lost three matches this season, and Sanjoy Sen may look to ring in radical changes in the team with its return leg of Federation Cup semifinal against Shillong Lajong FC slated in four days' time.
Goalkeeper Debjit Majumdar, defenders Kingshuk Debnath and Dhanachandra Singh and midfielder Pronay Haldar may also sit out of the starting line-up.
It means some players who have not played much this season and promising youngsters like Azharuddin Mallick will get the opportunity to impress at the big stage.
Fresh from his hattrick in a 5-0 hammering of Shillong Lajong in the home leg Sunday, Jeje Lalpekhula may play a key role in the frontline.
A win for Rambo's men will guarantee progression. However, if Yangon United and Maziya draw then South China simply need to replicate that result.
Rambo was impressed with how his players reacted to the pressure of being involved in such a must-win game against Yangon United and sounded confident that they can use this momentum to get past Mohun Bagan and into the knockout stages.
"The players were under quite a lot of pressure as we had been unable to get results in recent local matches," the 44-year-old said.
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