The mishap occurred at about 11.30 AM when cylinders exploded leading to a fire in the chemical manufacturing unit of Herbert Brown Pharmaceutical and Research Laboratories at Shivaji Udyog Nagar of MIDC phase-II area in Dombivili (East), a unit of the Acharya Chemicals.
"As of now, the number of dead is three and that of injured is 129," Thane District Collector Mahendra Kalyankar told PTI.
The injured were rushed to various hospitals in Thane, Dombivli and Kalyan, he said, adding, NDRF personnel were also involved in the rescue operation, along with fire brigade and police.
Chief Minister Devendra Fadnavis expressed grief at the mishap while Industries Minister Subhash Desai and Guardian Minister for the district Eknath Shinde visited the site along with Kalyankar.
Minister of state for Home Ram Shinde said an inquiry will be conducted into the incident.
Terming the incident as unfortunate, Fadnavis said he has asked the police and local authorities to speed up the operations.
Thane Joint Police Commissioner Ashutosh Dumbre said rescue operations were on as some more persons could be trapped in the debris.
He said the impact of the explosion was felt in an area of around five kilometres in which vehicles were damaged.
Over a dozen firefighters from Thane, Kalyan, Ambernath, Ulhasnagar, Badlapur and Navi Mumbai were rushed to the spot to extinguish the flames.
Police said the rescue team was facing a tough task in clearing the debris as chemical barrels and drums were lying buried under it.
Thane District Regional Disaster Management Cell
In-charge Santosh Kadam said the rescue operations were affected because of the fire and it was not immediately known how many persons were trapped inside.
The NRDF team from Pune was rushed to Dombivili to assist in the rescue operations.
"Saddened to know about the unfortunate & tragic incident that took place at Dombivali," Fadnavis tweeted.
"Spoke to police officials & local authorities and asked them to speed up the relief operations," he said.
"We are constantly in touch with the local administration and we would leave no stone unturned in our efforts & relief operation," he said in another tweet.
(Reopens BOM 13)
Chief Minister Fadnavis visited the accident site and also the hospital where some of the injured are admitted.
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