A stronger yen "capped the initial rise," said Yoshihiro Ito, chief strategist at Okasan Securities, wrote on his market blog.
The benchmark Nikkei 225 index lost 0.37 per cent, or 73.47 points, to 19,520.69. But the broader Topix index of all first-section issues rose 0.08 per cent, or 1.20 points, to 1,555.68.
The Nikkei opened higher after Wall Street scored gains for the second straight day this year and remaining within striking distance of the 20,000 point milestone.
US central bankers hinted they may need to raise interest rates faster than planned due to "considerable uncertainty" linked to US President-elect Donald Trump's fiscal stimulus plans, which could fan inflation, according to minutes of the final 2016 policy meeting in December at which the US central bank lifted rates.
"As long as you see positive numbers coming through on the economy, you're not going to see a change in rhetoric from the Fed," he said.
In Tokyo, shares in struggling auto parts maker Takata dipped following a surge on news last week of an expected settlement over a US criminal probe into exploding airbags.
That marked a more than 100-per cent rise since December 28 when the shares started climbing on hopes of a resolution.
Nintendo, meanwhile, was down 1.61 per cent at 24,085 yen, while Sony fell 1.11 per cent at 3,296 yen.
Market heavyweight Fast Retailing declined 1.61 per cent at 42,590 yen.
The USD, meanwhile, fell as the Fed minutes highlighted concerns about the impact of a strong currency on the new US administration's expected stimulatory economic policies.
A stronger yen hurts the profitability of Japan's major exporters, hitting demand for their shares.
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