Hanks, 59, whose latest film "The Bridge of Spies" is up for six Oscars, topped a Harris Poll that surveyed more than 2,200 adults in the US about the best Hollywood actor-actress, reported Variety.
Hanks also nabbed the title in 2002, 2004, 2005 and 2013.
Jumping up two spots from last year, Johnny Depp was runner-up.
Depp portrayed notorious gangster Whitey Bulger in 2015's "Black Mass". Neither Hanks nor Depp is up for a best actor Oscar, despite early buzz surrounding their performances. Both were also snubbed for a Golden Globe nomination.
The "Training Day" actor was honored with the coveted Cecil B DeMille Award earlier this month at the Globes.
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