Zverev's win earned him his first place in a Masters 1000 quarter-final and he will face the winner of Tuesday's late game between Australian Nick Kyrgios and Belgian David Goffin.
Roger Federer, Rafael Nadal and Kei Nishikori advanced to the quarter-finals on cue.
Swiss Wawrinka, beaten by Federer in the final of Indian Wells earlier this month, looked weary as he struggled through the third set of his match.
"I had one bad game to start the second set and then it was tough for me," Wawrinka, the reigning US Open champion, said. "I don't know. I completely went down physically and mentally, and also my tennis was completely out. I had no more gas."
Federer had to work hard for his victory against 14th seed Roberto Bautista Agut, emerging with a 7-6 (7/5) 7-6(7/4) win setting up a last eight meeting with Czech Tomas Berdych, the 10th seed, a 6-3, 7-5 winner over France's Adrian Mannarino.
"It was a different kind of match," said Federer, who is in an excellent run of form having won the Australian Open and Indian Wells already this year.
"That's where you got to keep a positive mindset and make the right plays," he added.
The first set was a close and entertaining battle. Bautista broke to go 5-4 up but Federer then won every point in the next two games. The tie-break saw some fantastic tennis from both players but the Swiss delivered at the close.
"I thought Roberto did a good job of making shots, staying offensive when he could, fending off a lot of good shots that I hit," Federer said. "Then it was tough. The sun was coming from the side in the beginning so it's hard to chase the lines.
- Nadal sets Sock clash -
=========================
Nadal beat France's Nicolas Mahut 6-4, 7-6 (7/4) in a tightly fought contest and will face American Jack Sock who comfortably beat his compatriot Jared Donaldson 6-2, 6-1.
The Spaniard, who has never won the Miami title, got the only break of the match to go 5-4 up in the first set and said he expected a strong challenge from Sock.
"He's a very aggressive player, very powerful player, big serve, big forehand, and a good backhand too. He plays quick with his backhand.
Sock is bubbling with confidence however.
"I'll definitely give myself a lot more chance to win this time around than maybe I did a few years ago. I'm 24 years old now and been on tour for a while. I'm playing these matches and hoping I can win and going in believing I can win for sure," said the American.
Nishikori, who lost to Novak Djokovic in last year's Miami final, will face Italian Fabio Fognini who defeated American Donald Young 6-0 6-4.
Disclaimer: No Business Standard Journalist was involved in creation of this content
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