"There are moments of significant agreement and then there are moments of tactical disagreement," US deputy secretary of state Antony Blinken told French radio station Europe 1.
"That's the nature of things and I imagine that will continue for the last two years of the Obama administration," added Blinken, who spoke in French.
Israeli Prime Minister Benjamin Netanyahu is poised to go to Capitol Hill on Tuesday for another round in an increasingly heated battle with the White House over Iran's nuclear ambitions.
Blinken stressed that Obama had spent more time in contact with Netanyahu than any other world leader but warned that the Israeli prime minister's speech could have "a bit of a corrosive effect" on ties.
"It does not create trust," said the diplomat, stressing nevertheless that "the US commitment to Israel's security will not change."
Blinken also called for a "political transition" in Syria that would eject President Bashar al-Assad from power.
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