Residents of Dolores, a city of 20,000 people about 165 miles (265 kilometers) west of Montevideo, shot images of their homes and cars being swept up by the tornado and posted them on social media.
"The president has ordered the deployment of all the resources in the state to attend to the situation in Dolores," said Juan Andres Roballo, an official with the Uruguayan president's office. The city was declared an emergency zone.
Fire department spokeswoman Mariela Vivone told Channel 12 television that two of the dead were killed by flying cars carried by the winds.
Local media outlets reported that some residents took advantage of the chaos to loot stores.
Roballo said that the police and military presence in the area would be increased.
