Sgt Jesse Grabow with the Minnesota State Patrol says the crash happened around 12.25 pm today in Callaway.
Grabow says crews are trying to put out the burning tanker. He says the town of about 200 was evacuated as a precaution.
Canadian Pacific says the crash derailed seven empty cars and the locomotive on the 82-car train. Railroad spokesman Andy Cummings tells KSTP-TV that two people were hurt and were offered medical services, but he didn't have details on their injuries.
Callaway is about 50 miles east of Fargo, North Dakota.
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