"I hope she gets well soon," Trump told Fox News in an interview when asked about the illness of Clinton.
Clinton, 68, is suffering from pneumonia and she had to leave the 9/11 memorial last morning.
"I don't know what's going on. I see what I see. The coughing fit was a week ago, so I assume that was pneumonia also. I mean, I think it would have been, so something's going on," he said in response to a question.
The first of the three debates are scheduled to be held in New York on September 26.
Trump appeared to be refuting speculation that Clinton might be replaced by Vice President Joe Biden because of her illness.
"I don't think they'll replace her. We have to see what's wrong. I mean, we have to see what's wrong. But whatever it is, it is. I'm ready, whatever it is," he said.
However, Trump said that the health has now become a presidential issue.
"This last week I took a physical and I'll be releasing when the numbers come in. Hopefully they're going to be good. I think they're are going to be good, I feel great. But when the numbers come in, I'll be releasing very, very specific numbers," he said.
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