The incident occurred in Langer House police station limits at around 12.10 am when the duo tried to avoid an drunken drive checking, they said.
According to a police official, Srinivas (19) and Rajesh (24) were going towards Gudimalkapur from Budvel when they saw barricades placed on a road as part of the drive against drunken driving.
The duo suddenly took a u-turn when they were hit by the lorry and were killed on the spot, he said.
The lorry driver has been taken into custody. A case was registered and probe is on, police said.
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