The group, a feared force battling President Bashar al-Assad, is now subject to an international asset freeze and arms embargo, according to an announcement made by the Security Council's Al-Qaeda sanctions committee.
France and Britain jointly sought Al-Nusra's designation after blocking a demand by the Syrian government.
Al-Nusra leader Abu Mohammed al-Jawlani last month pledged allegiance to Al-Qaeda chief Ayman al-Zawahiri, confirming suspicions of ties between the rebel group and the militant group founded by the late Osama bin Laden.
Western nations are acting against Al-Nusra in a bid to shore up moderate opponents of Assad. The 26-month old Syrian conflict has left more than 94,000 dead, according to Syrian activists.
Experts have said Al-Nusra gets aid from Al-Qaeda's Iraqi affiliate and the Security Council announcement specifically mentions links to Al-Qaeda in Iraq.
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