The Eastern Ghouta suburb, home to 400,000 residents, has been besieged since 2013 and humanitarian conditions there have deteriorated sharply amid violence that intensified since November 14.
The Syrian Observatory for Human Rights says at least 202 people, including 47 children, have been killed since.
The area, the last remaining rebel-held pocket near the capital Damascus, is technically part of a "de-escalation zone" brokered by Russia earlier this year.
Syrian opposition and government delegates are currently in Geneva for a new round of U.N.-sponsored talks after a short break. The government delegation has protested the opposition's insistence on the absence of President Bashar Assad from any future transition period.
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