Britain, France and the United States are pushing for a ban on the sale of helicopters to Syria and sanctions on 11 Syrians and 10 entities linked to chemical attacks in the nearly six-year war.
A joint investigation by the United Nations and the Organization for the Prohibition of Chemical Weapons (OPCW) has concluded that the Syrian military carried out chemical attacks against three villages in 2014 and 2015.
"The US, UK and France are very clear that this is an issue of principle," he said, adding that Russia's ambassador said at a meeting last week that Moscow would block the measure.
Russia has used its veto six times to shield its Damascus ally from any punitive action.
China, another veto-wielding Security Council member, is expected to abstain in the vote.
France and Britain presented drafts on imposing sanctions on Syria in December, but held off on action to give the new US administration time to study it.
These commanders are said to have been involved in attacks by helicopters that dropped chlorine barrel-bombs on the villages of Qmenas, Talmenes and Sarmin.
Syria has denied using chemical weapons while Russia has dismissed the panel's findings as "inconclusive."
The Security Council is due to discuss chemical weapons use in Syria during a meeting on Friday.
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