Saudi news websites reported that security forces had foiled an attack around the Al-Salam palace that left the attacker and at least two Saudi guards killed.
There was no official confirmation of the incident.
"Due to the possibility of ongoing police activity, American citizens are advised to exercise caution when travelling through the area," the embassy said in a brief statement.
The warning comes after the Saudi police raided hideouts of a "terror" cell linked to the Islamic State group this week, killing two people and arresting five, according to the national security agency.
Since late 2014, IS has claimed a series of bombings and shootings against Shiites and security forces in the Sunni- majority kingdom.
Saudi Arabia is a member of the US-led international coalition that has been battling the Sunni extremist group in Syria and Iraq.
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