The comments yesterday marked the first time the US military has acknowledged that the air war may have exacted a toll on civilians.
US Central Command, which is overseeing the air campaign, initially looked into 18 cases and concluded 13 were not credible but five merited further review. Of those, two incidents -- one in Iraq and one in Syria -- prompted formal investigations, defence officials told AFP.
The current probes involved one case that occurred as recently as December 26, officials said.
"This is something we always take seriously. We are very mindful of trying to mitigate the risk to civilians every time we operate, everywhere we operate."
His comments marked a shift as the Pentagon had insisted for months they had not confirmed any instance of civilian deaths from the bombing raids.
Human rights organisations, however, have previously reported that dozens of civilians have been killed in the US-led air strikes, mainly in Syria.
"It would be highly unlikely that there would be no civilian casualties at this stage in the air campaign," said one US defence official, speaking on condition of anonymity.
But the American military was not on the ground in Syria and had a relatively small presence in Iraq, so it was difficult to say definitively how many civilians may have been killed in the air war so far, the official added.
"A source is generally deemed to be credible if the source provides verifiable information, such as corroborating statements, photographs or documentation that can help us determine whether an allegation is founded," Kellogg said.
But the two formal investigations currently under way "are the direct result of our own internal review process and not the result of allegations received from outside of DoD (the Department of Defence)," he said in a statement.
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