The State Department said Ghandour is a former Hamas Shura council and political bureau member who now leads a Hamas brigade in Gaza.
Ghandour "has been involved in many terrorist operations," it said, including a 2006 attack on an Israeli military outpost at the Kerem Shalom border crossing which left two Israeli soldiers dead and four wounded.
That attack resulted in the kidnapping of Israeli soldier Gilad Shalit, who was held by Hamas for five years before he was freed in exchange for the release of 1,027 Palestinian prisoners.
The terrorist designation effectively bans Americans from any involvement or business relations with Ghandour.
In response to the State Department's action Thursday, Hamas spokesman Sami Abu Zuhri called it "an attempt to invert the real situation, because the real terrorist is the one who furnishes the arms of the occupier (Israel) to kill the children of Palestine," an allusion to the United States.
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