It was the first time the Treasury Department had imposed sanctions on an IS member accused of involvement in chemical weapons, the department said.
The sanctioned men included senior IS leader Attallah Salman Abd Kafi al-Jaburi, who is in charge of bomb-making facilities in the Iraqi province of Kirkuk, Treasury said in a statement.
The State Department also listed Iraqi IS leader Marwan Ibrahim Hussayn Tah al-Azawi, who also is connected to the manufacture of chemical weapons, as a "specially designated global terrorist."
The department condemned the use of chemical weapons "and will leverage all available tools to target those complicit in their development, proliferation, or use," John Smith, head of Treasury's sanctions office, said.
In November, IHS Conflict Monitor, a London based intelligence analysis service, accused the Islamic State group of having used chemical weapons at least 52 times since the militant organization swept to power in 2014.
Separately, the State Department also designated the Indonesian militant organization Majelis Mujahidin Indonesia, accused of involvement in attacks in that country including the May 2012 attack on a book launch by the Canadian author Irshad Manji.
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