US Secretary of State John Kerry and his Russian counterpart Sergei Lavrov are in talks following Moscow's surprise initiative to finalise an agreement on eliminating Syrian President Bashar al-Assad's chemical weapons.
"We need to see concrete actions to demonstrate that Assad is serious about giving up his chemical weapons," Obama said in his weekly address.
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The Russian plan has led Obama to put on hold planned military strikes in response to an August 21 chemical attack outside Damascus that Washington blames on the regime and says killed more than 1,400 people.
"We're making it clear that this can't be a stalling tactic," Obama said of the discussions in Geneva.
"Any agreement needs to verify that the Assad regime and Russia are keeping their commitments: that means working to turn Syria's chemical weapons over to international control and ultimately destroying them," he added.
"This would allow us to achieve our goal -- deterring the Syrian regime from using chemical weapons, degrading their ability to use them, and making it clear to the world that we won't tolerate their use."
The United States has estimated that Syria possesses around 1,000 metric tonnes of various chemical agents, including mustard and sarin gas, sulfur and VX.
The Russian estimates had been initially much lower, a senior US administration official said.
Obama pointed to "indications of progress" after the Assad regime acknowledged for the first time that it possessed chemical weapons and applied to join the 1993 Chemical Weapons Convention.
"We'll keep working with the international community to see that Assad gives up his chemical weapons so that they can be destroyed," the president said.
"We will continue rallying support from allies around the world who agree on the need for action to deter the use of chemical weapons in Syria.
"And if current discussions produce a serious plan, I'm prepared to move forward with it.
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