On the military front, the Pentagon said it may launch more air strikes and even direct ground attacks by special forces against jihadists seeking to carve out an Islamic caliphate in Iraq and Syria.
And on the diplomatic side, the State Department said it expected Damascus's key ally Iran to be invited to a new round of talks in Vienna this week on a political solution.
"An invitation to Iran to participate, I think Iranian leaders can take to mean that it's a genuine multilateral invitation," department spokesman John Kirby said.
Friday's talks in Vienna are seen as a way to end Syria's civil war by creating an interim unity regime and paving the way for President Bashar al-Assad's exit.
But, in parallel to this fledgling political process, a US-led coalition is carrying out an air campaign against Islamic State fighters in Iraq and Syria.
Testifying to lawmakers, Defense Secretary Ashton Carter said US forces would not shy away from "direct action on the ground" if they see a chance to hit IS targets.
These troops have a "train and advise" role to help Iraqi forces battling the extremist group but were recently drawn into fighting in northern Iraq.
Last week, a US soldier died during a raid in which commandos and Kurdish peshmerga stormed an IS-run jail in northern Iraq and freed 70 captives.
Afterwards, Carter said he expected "more of this kind of thing" and on Tuesday he told senators the coalition would focus on the IS stronghold of Raqa, in Syria.
"This will include more strikes against ISIL high-value targets as our intelligence improves.
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