State Department spokeswoman Jen Psaki said President Barack Obama had directed US intelligence to gather information about the reported attack near Damascus.
"At this time right now, we are unable to conclusively determine CW use, but we are focused every minute of every day since these events happened yesterday on doing everything possible within our power to nail down the facts," Psaki said.
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Obama has said that chemical weapons use by the Syrian regime would cross a US "red line," but Washington so far has not acted on earlier reports of chemical weapons attacks.
"If these reports are true, it would be an outrageous and flagrant escalation of use of chemical weapons by the regime," Psaki said.
"The president of course has a range of options that we've talked about before that he can certainly consider and of course discuss with his national security team," she said.
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