Flights were grounded and tens of thousands of homes lost power as intense winds overturned cars, uprooted large trees and snapped power lines. Large swaths of the city of Washington, Illinois, were flattened, yesterday.
President Barack Obama was briefed about the storms and will receive regular updates, the White House said.
Illinois Emergency Management Agency chief Jonathon Monken told CNN at leave five people had been killed -- including two in the far southern tip of the state and one in Washington -- as he warned that the number of injuries would likely increase "significantly."
Joseph Hoy, 80, was found dead on his farm while his 78-year-old sister Frances was pronounced dead in hospital.
"It just happened so fast," said Styninger, who lives just two miles (around three kilometers) from the Hoy farm.
Local television reported at least 37 people were being treated by a medical center in Illinois, seven of them with "severe" injuries.
Monken said at least 70 homes were completely destroyed in two different areas, and hundreds were damaged less severely. Four Red Cross shelters have been opened in the affected zone.
In Indiana, local media reported damage to commercial buildings, including a destroyed bank branch.
More than 64,600 homes lost power, according to Duke Energy. In the metropolitan area of the state capital Indianapolis, Indianapolis Power & Light reported nearly 16,000 without power.
"Absolute destruction," WMBD31 news reporter Alexandra Sutter wrote on Twitter in describing the scene.
Sutter later tweeted, after speaking with the mayor of the storm-hit town of Washington: "I asked what we can report to help. He said only 'please pray.'"
A photo posted on the station's Facebook page showed someone holding a tennis ball-sized piece of hail.
"Pay attention to all weather alerts and stay home and inside if possible," Illinois Governor Pat Quinn warned residents, adding that the severe weather was "very serious.
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