Vice President Kamala Harris in Paris for US-France fence-mending trip

US Vice President Kamala Harris kicked off a four-day visit to Paris and charm offensive Tuesday aimed at shoring up relations with France, America's oldest ally.

Washington's relationship with Paris hit a historic low this year after a U.S.-British submarine deal with Australia scuttled a French contract to sell subs to the Australian navy. Late last month, President Joe Biden told French President Emmanuel Macron the U.S. had been clumsy in its handling of the issue.

Harris started her trip by meeting with American and French scientists working on COVID-19 preparedness at the Pasteur Institute in Paris.

She said the visit underscored joint determination to tackle global challenges, especially to end the coronavirus pandemic.

Some of the most significant discoveries in science on any issue, from rabies to HIV-AIDS, to breast cancer, to mRNA and what we do around vaccines and pandemics, have occurred here in collaboration with French scientists, American scientists, scientists around the world coming together," Harris, a former California senator, said.

She also mentioned the institute's personal symbolism: Her late mother Shyamala Gopalan, who was a scientist, conducted breast cancer research with the institute's scientists in the 1980s.

Harris is scheduled to sit down with French President Emmanuel Macron at the lyse Palace on Wednesday for talks expected to focus on ways the two nations can better coordinate their efforts in the Indo-Pacific.

Harris and Macron are also expected to discuss global health, space and other issues. Harris is set to deliver a Thursday speech at the annual Paris Peace Forum and to participate Friday in the Paris Conference on Libya.