Human cells cultivated with the newly-discovered protein, dubbed "Dsup" for "damage suppressor", experienced half as much decay as normal cells when blasted with radiation.
"We were really surprised," said lead author Takuma Hashimoto, a biologist at the University of Tokyo who designed the experiments.
"It is striking that a single gene is enough to improve the radiation tolerance of human cultured cells," he told AFP, referring to the tardigrade-derived protein.
Tardigrades, as the water bears are more prosaically known, have long fascinated scientists with their veritable superpowers of survival.
Seemingly eyeless, they have bodies resembling hazmat suits, eight puffy legs with bear-like claws, and a vacuum-cleaner nozzle of a snout.
Most eat moss and lichen. Some feed on other water bears.
Remarkably, these primitive water-dwellers can withstand environments more extreme than anything found in Nature.
That includes being plunged into scalding liquids or frozen at temperatures just shy of absolute zero.
In an earlier experiment, water bears were given a 26-hour bath in -253 degree Celsius (-423 degree Fahrenheit) liquid nitrogen. The deepest chill ever recorded on Earth was a relatively balmy -89.2 C (-128.6 F) in Antarctica.
Some tardigrade species -- there are about 1,000 in all -- can handle crushing pressure at least six times greater than found at the 11-kilometre (seven-mile) deep Mariana Trench in the Pacific Ocean.
Even the ravages of outer space don't seem to faze them.
In 2007, thousands of water bears, attached to a satellite, were exposed directly to potentially-deadly space radiation in vacuum conditions and then brought back to Earth.
Not only did many survive, some females later laid eggs which yielded healthy offspring.
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