The four-year survey warned of serious threats to homes and infrastructure and industry in the face of extreme weather events.
President Barack Obama vowed during his victorious 2008 presidential campaign to make the United States a leader in tackling climate change and the "security threat" it poses.
But he has failed to convince Congress to take significant action during his subsequent years in office.
As part of a new push on the issue this week, Obama was to give televised interviews with various meteorologists Tuesday to discuss the findings of the third US National Climate Assessment.
The researchers warned of drought in the state of California, prairie fires in Oklahoma and rising ocean levels on the East Coast, particularly in Florida, most of them caused by humans.
Sea level rise is also eating away at low-lying areas in places like Mississippi.
In the Southeast and Caribbean regions, home to more than 80 million people and some of the nation's fastest-growing metropolitan areas, "sea level rise combines with other climate-related impacts and existing pressures such as land subsidence, causing significant economic and ecological implications."
The impact of global warming is unevenly distributed across US territory, with spectacular effects in Alaska, which researchers said warmed twice as fast as the rest of the country.
