As of Sunday, 635 cases of haemorrhagic fever (most confirmed to be Ebola), including 399 deaths, have been reported across Guinea, Liberia and Sierra Leone, making the outbreak the largest ever "in terms of the number of cases and deaths as well as geographical spread," WHO said.
"Drastic action is needed," the UN agency stressed in a statement, warning of the danger that the virus could jump to other countries.
Earlier this week, medical charity Doctors Without Borders (MSF) also said the outbreak of the virus, which is deadly in up to 90 per cent of cases, was "out of control".
Despite the efforts of the WHO and others, there has been a "significant increase" in the number of cases and deaths reported each day for the past three weeks, it said.
The agency is now "gravely concerned (by) the on-going cross-border transmission into neighbouring countries as well as the potential for further international spread," said WHO's regional director for Africa, Dr. Luis Sambo.
"This is no longer a country specific outbreak but a sub-regional crisis that requires firm action by governments and partners," Sambo warned.
"One case can restart an entire epidemic," he warned, justifying the dramatic measures needed to contain the virus, which spreads through bodily fluids including sweat, meaning you can get sick from simply touching an infected person.
To address the growing crisis, the WHO said Thursday it would convene a meeting of the health ministers from 11 countries in Accra, Ghana on July 2 and 3 "to discuss the best way of tackling the crisis collectively as well as develop a comprehensive inter-country operational response plan."
Sierra Leone, which has seen 46 confirmed Ebola deaths, will also be there.
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