From 1970 to 2010, there was a 39-per cent drop in numbers across a representative sample of land- and sea-dwelling species, while freshwater populations declined 76 per cent, the green group WWF said in its 2014 Living Planet Report.
Extrapolating from these figures, "the number of mammals, birds, reptiles, amphibians and fish across the globe is, on average, about half the size it was 40 years ago," it said.
The 52-per cent decrease confirmed mankind was chomping through Nature's bounty much faster than the rate of replenishment, the WWF warned.
The new report tracks the growth or decline of more than 10,000 populations of 3,038 species ranging from forest elephants to sharks, turtles and albatrosses.
It stressed that humans were consuming natural resources at a rate that would require 1.5 Earths to sustain - cutting down trees faster than they mature and harvesting more fish than oceans can replace.
"We are using nature's gifts as if we had more than just one Earth at our disposal," WWF Director General Marco Lambertini said in the foreword to the biennial publication.
While agricultural yield per hectare has improved through better farming and irrigation methods, the sheer human population explosion has reduced per capita "biocapacity", or available life-sustaining land.
Human population numbers shot up from about 3.7 billion to nearly seven billion from 1970 to 2010.
"So while biocapacity has increased globally, there is now less of it to go around," the report said.
And, it warned, "with the world population projected to reach 9.6 billion by 2050 and 11 billion by 2100, the amount of biocapacity available for each of us will shrink further".
"Low-income countries have the smallest footprint, but suffer the greatest ecosystem losses," it said.
The wildlife decline was worst in the tropics with a 56 per cent drop, compared with 36 per cent in temperate regions.
Latin America suffered the most drastic losses with an overall decline of 83 per cent.
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