Cameron announced that parents in Britain would face prosecution for failing to prevent their daughters from being subjected to FGM, while setting out steps to tackle both practices in developing nations.
"Our aim is to outlaw FGM and child marriage everywhere for everyone," Cameron told the summit in London, to applause from an audience of experts and campaigners from around the world.
FGM, which affects tens of millions of women, particularly in the Horn of Africa, ranges from removal of the clitoris to the mutilation and removal of other female genitalia. It can leave girls at risk of prolonged bleeding, infection, infertility and even death.
But he argued: "All girls have the right to live free from violence and coercion, without being forced into marriage or the lifelong physical and psychological effects of female genital mutilation.
"Abhorrent practices like these, no matter how deeply rooted in societies, violate the rights of girls and women across the world, including here in the UK.
"I want to build a better future for all our girls and I am hosting the Girl Summit today so that we say with one voice -- let's end these practices once and for all."
The summit will also launch new programmes to prevent child and forced marriage in 12 developing nations.
Speakers at the event included Malala Yousafzai, the Pakistani schoolgirl who recovered from being shot in the head by the Taliban and is now a campaigner for girls' education.
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