Meeting in Beijing with US national security adviser Susan Rice, Xi said that he looks forward to continuing a dialogue with Obama next month and working to ensure that China-US relations keep expanding.
"China attaches great importance to the growth of the China-US relationship," Xi said.
"We stand ready to further promote our practical cooperation, effectively manage the sensitive issues between us and strengthen the friendship between the people of both countries."
"At the same time, we obviously have issues of difference and some difficulty that we need to work through and we will continue to do so," she said.
Xi's visit to the US comes as the countries have shown a willingness to cooperate on global matters ranging securing a nuclear deal with Iran to climate change.
But they have also clashed over issues including what Washington and some regional countries see as China's increasing assertiveness in Asia as well as its territorial disputes with countries close to the US such as the Philippines and Japan.
Rice told state councillor Yang Jiechi, China's top foreign policy official of the latter that both sides "acknowledge their need to be addressed effectively".
Yang said China and the US will stay in close communication on subjects including "the Iran and North Korean nuclear issues" and climate change, along with questions of "regional rights and interests".
That could refer to the South China Sea and East China Sea, where Beijing is embroiled in territorial disputes with its Southeast Asian neighbours and US treaty ally Japan respectively.
Beijing and Washington have also worked together as members of the six-party talks on North Korea's nuclear programme, which also take in Tokyo, Seoul, Moscow and Pyongyang.
That forum has been essentially dormant for years though China, which serves as host, supports its revival.
Rice also met with Fan Changlong, a vice chairman of the Communist Party's powerful Central Military Commission, which is chaired by Xi.
The US envoy said Washington was "deeply committed to building a healthy, stable, reliable military-to-military relationship with China" and stressed an agreement last year to "reduce the risk of unintended consequences" in encounters.
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