The centre of the outbreak is the capital Luanda's eastern suburb of Viana where 29 deaths and 92 cases have been reported over the last six weeks, national director of public health Adelaide de Carvalho said.
There is no specific treatment for the viral hemorrhagic disease which is transmitted by infected mosquitoes and found in tropical regions of Africa and Latin America's Amazon region.
Authorities have launched a mass vaccination drive targeting about 1.5 million people.
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