The 37-year-old actor played ruthless villain Sylar in the original series, who was able to extract the powers of others by slicing through their skull, reported The Wrap.
Quinto revealed that he has been in talks with creator Tim Kring about reprising his role.
"I've been talking to Tim and I'm really excited that they're doing that show. I don't really see the room for me to be involved at this point, just based on my schedule. But, I'm not sure if it will work out just based on availability alone," he said.
Since appearing in 'Heroes', Quinto has gone on to star as Spock in 'Star Trek' and 2013 follow-up 'Star Trek Into Darkness', as well as 'American Horror Story'.
NBC has already got Jack Coleman to rejoin as Noah Bennet and more original stars are likely to return.
Milo Ventimiglia, who played Peter Petrelli, has ruled himself out of 'Heroes Reborn', while Hayden Panettiere (Claire Bennet) said she had received no contact about the project back in April.
NBC has ordered 13 episodes of the spin-off series, which will air in 2015.
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