Bilal Sheikh, the chief security officer of President Zardari here and a prominent leader of the Pakistan Peoples Party (PPP), was killed when the bomb ripped through his double cabin car in Gurumandir area, one of the city's busiest locations.
A presidential spokesman told PTI that Zardari is in Karachi but he was nowhere near the attack and was completely safe.
Rescue teams have shifted four dead and 12 injured people to hospitals, rescue official Anwar Kazmi told PTI.
Aslam said apparently the remote controlled bomb was planted in the double cabin car and was detonated when the car was at Gurumandir, where it stopped for a while.
"It was a remote controlled bomb and it caused lot of damage," a police official of the area said.
Usman Bajwa, another police official, told the media that the bullet proof car was not properly built as it failed to sustain the impact of the bombing.
An official of the bomb disposal squad told Geo TV that four kilogrammes of explosives were used in the attack.
Zardari and Prime Minister Nawaz Sharif "strongly condemned" the attack, state media said.
Sheikh, a die-hard leader of the PPP was party president of the central district in Karachi.
"He had received several threats and a cracker bomb attack was also carried out against him in Nazimabad two months back. He was transferred from the Presidency to Karachi," an officer said.
Television channels gave conflicting reports that the bomb was planted on the roadside and was detonated when the car passed it.
An eyewitness said that besides the those in the car several other bystanders were injured by the blast. Some vehicles which were close were also damaged.
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