Shadow foreign secretary Hilary Ben was sacked after he said he no longer had confidence in Corbyn's leadership. Soon after, his colleague, shadow health secretary Heidi Alexander announced her resignation on Twitter.
Next to go were Gloria de Piero, shadow minister for young people and voter registration, and Ian Murray, shadow minister for Scotland.
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The shock decision by the country to vote to leave the 28-member European Union was against the wishes of most Labour lawmakers.
"There is no confidence to win the next election if Jeremy continues as leader. In a phone call to Jeremy I told him I had lost confidence in his ability to lead the party and he dismissed me," Ben said.
Reports suggest that Benn has been encouraging shadow ministers to resign if Corbyn ignored a motion of no confidence.
"At this absolutely critical time for our country following the EU referendum result, the Labour Party needs strong and effective leadership to hold the government to account. We don't currently have that and there is also no confidence we would be able to win a general election as long as Jeremy remains leader," Benn told BBC, ruling out his own ambitions to stand for party leadership.
67-year-old Corbyn faces a vote of no confidence over claims he was "lacklustre" and "half-hearted" during the EU referendum campaigning.
Labour MPs Dame Margaret Hodge and Ann Coffey had submitted a motion of no confidence against Corbyn to Parliamentary Labour Party (PLP) chairman John Cryer soon after the results of the EU referendum in favour of Brexit.
The motion has no formal constitutional force but calls for a discussion at the PLP's next meeting tomorrow. The chairman will decide whether it is debated. If accepted, a secret ballot of Labour MPs could be held on Tuesday.
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