The multi-vehicle collision occurred early today on the Yuegan Expressway, which links Guangdong's Heyuan City and Jiangxi's Ganzhou City.
The accident happened when a truck loaded with wood rolled over due to faulty brakes, triggering a collision with three other trucks, a mini bus and a car.
The other five vehicles caught fire after the collision.
The injured people have been hospitalised, state-run Xinhua news agency reported citing local authorities.
Road accidents, often because of dangerous driving and a disregard for traffic rules, are a major problem in China.
According to the World Health Organisation, China has the second-most annual traffic fatalities after India.
In July, at least 38 people were killed when a van carrying inflammable liquid hit a bus on a highway in central China.
While in June 2013, more than 40 people were killed in a blaze in a bus in eastern China.
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